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Methylone (also known as "3,4-methylenedioxy-N-methylcathinone",
"MDMC", "βk-MDMA" and by the slang term "M1") is an empathogen and
stimulant psychoactive drug. It is a member of the substituted
amphetamine, substituted cathinone and substituted
Methylone is the substituted cathinone analog of MDMA and the
3,4-methylenedioxy analog of methcathinone. The only structural
difference of methylone with respect to MDMA is the substitution of
2 hydrogen atoms by 1 oxygen atom in the β position of the
phenethylamine core, forming a ketone group.
Methylone was first synthesized by the chemists Peyton Jacob III
and Alexander Shulgin in 1996 for potential use as an
Starting around 2004, methylone has been sold for recreational use,
taking advantage of the absence of legal prohibition of this
compound in many countries.
Ethylone acts as a mixed reuptake inhibitor/releasing agent of
serotonin, norepinephrine, and dopamine.These are the
neurotransmitters in charge of pleasure, reward, motivation and
This is done by inhibiting the reuptake and reabsorption of the
neurotransmitters after they have performed their function of
transmitting a neural impulse, essentially allowing them to
accumulate and be reused, causing physically stimulating and
In comparison to methylone, it has approximately over 3x lower
affinity for the serotonin transporter (which itself has 3x lower
affinity than MDMA), while its affinity for the norepinephrine and
dopamine transporters is similar.
The results of these differences in pharmacology relative to
methylone is that ethylone is less potent in terms of dose, has
more balanced catecholaminergic effects relative to serotonergic,
and behaves more like a reuptake inhibitor like methylphenidate
than a releaser like amphetamine; however, ethylone still has
relatively robust releasing capabilities.
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