1. Quick details
|Delivery Time||Within 2 days after receive payment|
|PackAge||Aluminum foil bag|
|Production Capacity||500 Kilogram/Month|
|Storage||store in dry and cool place.|
|Application||For lab research|
s an opioid analgesic drug developed by a team at Upjohn in the
1970s that acts as a selective agonist of the µ-opioid receptor
with a Kd value of 5.3 nM compared to 910 nM for the κ-opioid
receptor and has around 7.5 x the potency of morphine in animal
is a structural isomer of the earlier opioid AH-7921 and the result
of a great deal of work elucidating the quantitative
structure–activity relationship of the scaffold.
Upjohn looked for the key moieties which gave the greatest
activity and posted over a dozen patents on related compounds,
each optimizing one moiety] until they discovered that U-47700 was
the most active.
ecame the lead compound of selective kappa-opioid receptor ligands
such as U-50488, U-51754 (containing a single methylene spacer
difference) and U-69,593, which share very similar structures.
Although not used medically, the selective kappa ligands are used
The way in which opioids structurally mimic these natural
endorphins results in their euphoria, pain relief and anxiolytic
effects. This is because endorphins are responsible for reducing
pain, causing sleepiness, and feelings of pleasure. They can be
released in response to pain, strenuous exercise, orgasm, or
may also be an agonist for the kappa-opioid receptor system. As a
result of this, it has become the lead compound of selective
kappa-opioid receptor ligands such as U-50488 and U-69,593, which
share very similar structures. Its structure led to other chemists
experimenting with it to see if rigid analogues would retain
activity. Although not used medically, the selective kappa ligands
are used in research.
4. Company Introduction
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