U47700 Research Chemical Intermediates CAS 82657-23-6 Fomula
1. Quick details
|Delivery Time||Within 2 days after receive payment|
|PackAge||Aluminum foil bag|
|Production Capacity||500 Kilogram/Month|
|Storage||store in dry and cool place.|
|Application||For lab research|
U-47700 is an opioid analgesic drug developed by a team at Upjohn
in the 1970s that acts as a selective agonist of the µ-opioid
receptor with a Kd value of 5.3 nM compared to 910 nM for the
κ-opioid receptor and has around 7.5 x the potency of morphine in
U-47700 is a structural isomer of the earlier opioid AH-7921 and
the result of a great deal of work elucidating the quantitative
structure–activity relationship of the scaffold.
Upjohn looked for the key moieties which gave the greatest
activity and posted over a dozen patents on related compounds,
each optimizing one moiety] until they discovered that U-47700 was
the most active.
U-47700 became the lead compound of selective kappa-opioid receptor
ligands such as U-50488, U-51754 (containing a single methylene
spacer difference) and U-69,593, which share very similar
structures. Although not used medically, the selective kappa
ligands are used in research.
The way in which opioids structurally mimic these natural
endorphins results in their euphoria, pain relief and anxiolytic
effects. This is because endorphins are responsible for reducing
pain, causing sleepiness, and feelings of pleasure. They can be
released in response to pain, strenuous exercise, orgasm, or
U-47700 may also be an agonist for the kappa-opioid receptor
system. As a result of this, it has become the lead compound of
selective kappa-opioid receptor ligands such as U-50488 and
U-69,593, which share very similar structures. Its structure led to
other chemists experimenting with it to see if rigid analogues
would retain activity. Although not used medically, the selective
kappa ligands are used in research.
4. Company Introduction
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