1. Quick details
|Delivery Time||Within 2 days after receive payment|
|PackAge||Aluminum foil bag|
|Production Capacity||500 Kilogram/Month|
|Storage||store in dry and cool place.|
|Application||For lab research|
U-48800 is an opioid analgesic drug developed by a team at Upjohn
in the 1970s that acts as a selective agonist of the µ-opioid
receptor with a Kd value of 5.3 nM compared to 910 nM for the
κ-opioid receptor and has around 7.5 x the potency of morphine in
structural isomer of the earlier and the result of a great deal of
work elucidating the quantitative structure–activity relationship
of the scaffold.
Upjohn looked for the key moieties which gave the greatest
activity and posted over a dozen patents on related compounds,
each optimizing one moiety] until they discovered that U-47700 was
the most active.
U-48800 became the lead compound of selective kappa-opioid receptor
ligands such as U-50488, U-51754 (containing a single methylene
spacer difference) and U-69,593, which share very similar
structures. Although not used medically, the selective kappa
ligands are used in research.
The way in which opioids structurally mimic these natural
endorphins results in their euphoria, pain relief and anxiolytic
effects. This is because endorphins are responsible for reducing
pain, causing sleepiness, and feelings of pleasure. They can be
released in response to pain, strenuous exercise, orgasm, or
be an agonist for the kappa-opioid receptor system. As a result of
this, it has become the lead compound of selective kappa-opioid
receptor ligands such as U-50488 and U-69,593, which share very
similar structures. Its structure led to other chemists
experimenting with it to see if rigid analogues would retain
activity. Although not used medically, the selective kappa ligands
are used in research.
4. Company Introduction
Dongmao Biotechnology Co., Limited specializes in exporting high
quality Research chemical, medical intermediate, Pharmaceutical
chemicals and so on.
Our products are produced on the basis of best technical team,
advanced equipment, high qualified management which meets the
requirements of security and environmental protection.
We earned customers' trust and created a good reputation during
these years. we are committed to providing excellent quality
products and the perfect service to friends all over the world.
We will provide the most comprehensive products and service to you!
We are looking forward to your cooperation.
1. How is the quality?
The qualities of most products are above 99% purity, same are 99.7%
2. How is the package?
Aluminum foil bag or as customer's required.
3. How is the storage?
Keep in dry and cool place.
4. Do I need to pay extra for shipping cost?
No, our price includes the shipping cost already; you need not pay
for any tax and others.
5. Can I order sample to test?
Yes, you are welcome to order sample before placing bulk order. We
will send the sample directly to your door by courier.