1. Quick details
|Means Of Transport:||Air||Package:||In Foil Bag Or Customized|
|Product Name:||U48800||Production Capacity:||500kg/month|
developed by a team at Upjohn in the 1970s that acts as a selective
agonist of the µ-opioid receptor with a Kd value of 5.3 nM compared
to 910 nM for the κ-opioid receptor and has around 7.5 x the
potency of morphine in animal models.
structural isomer of the earlie and the result of a great deal of
work elucidating the quantitative structure–activity relationship
of the scaffold.
Upjohn looked for the key moieties which gave the greatest
activity and posted over a dozen patents on related compounds,
each optimizing one moiety] until they discovered that was the most
became the lead compound of selective kappa-opioid receptor ligands
such as U-50488, U-51754 (containing a single methylene spacer
difference) and U-69,593, which share very similar structures.
Although not used medically, the selective kappa ligands are used
may also be an agonist for the kappa-opioid receptor system. As a
result of this, it has become the lead compound of selective
kappa-opioid receptor ligands such as U-50488 and U-69,593, which
share very similar structures. Its structure led to other chemists
experimenting with it to see if rigid analogues would retain
activity. Although not used medically, the selective kappa ligands
are used in research.
5. Company Introduction
Dongmao Biotechnology Co., Limited specializes in exporting high
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chemicals and so on.
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