U 47700 Research Chemical Powders , Analgesic Opioid Research
Chemicals CAS 82657-23-6
U-47700 U47700 Powder
U-47700 is an opioid analgesic drug developed by a team at Upjohn
in the 1970s that acts as a selective agonist of the µ-opioid
receptor with a Kd value of 5.3 nM compared to 910 nM for the
κ-opioid receptor and has around 7.5 x the potency of morphine in
U-47700 is a structural isomer of the earlier opioid AH-7921 and
the result of a great deal of work elucidating the quantitative
structure–activity relationship of the scaffold.
Upjohn looked for the key moieties which gave the greatest activity
and posted over a dozen patents on related compounds, each
optimizing one moiety until they discovered that U-47700 was the
U-47700 became the lead compound of selective kappa-opioid receptor
ligands such as U-50488, U-51754 (containing a single methylene
spacer difference) and U-69,593, which share very similar
Although not used medically, the selective kappa ligands are used
Systematic (IUPAC) name:
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