Legal Research Chemicals BK MDMA M1 Research Chemical Intermediates
Methylone (also known as "3,4-methylenedioxy-N-methylcathinone",
"MDMC", "βk-MDMA" and by the slang term "M1") is an empathogen and
stimulant psychoactive drug. It is a member of the substituted
amphetamine, substituted cathinone and substituted
Methylone is the substituted cathinone analog of MDMA and the
3,4-methylenedioxy analog of methcathinone. The only structural
difference of methylone with respect to MDMA is the substitution of
2 hydrogen atoms by 1 oxygen atom in the β position of the
phenethylamine core, forming a ketone group.
Methylone was first synthesized by the chemists Peyton Jacob III
and Alexander Shulgin in 1996 for potential use as an
antidepressant. Starting around 2004, methylone has been sold
forrecreational use, taking advantage of the absence of legal
prohibition of this compound in many countries.
Methylone substitutes for bkMDMA in rats trained to discriminate
MDMA from saline. Methylone does not substitute for amphetamine or
for the hallucinogenic DOM in animals trained to discriminate
between these drugs and saline.
Further, also in common with MDMA, methylone acts on monoaminergic
systems. In vitro, methylone has one third the potency of MDMA at
inhibiting platelet serotonin accumulation and about the same in
its inhibiting effects on the dopamine and noradrenaline
In spite of these behavioral and pharmacological similarities
between methylone and MDMA, the observed subjective effects of both
drugs are not completely identical. Alexander Shulgin wrote of the
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